Azilit ^TM

Pharmacology

Azithromycin is an azalide antibiotic, subclass of macrolide class of antibiotics. Azithromycin acts by binding to the 50S ribosomal subunit of susceptible organisms and thus interferes with microbial protein synthesis. Azithromycin demonstrated activity in vitro, against a wide range of gram-positive and gram-negative bacteria including: Staphylococcus aureus, Streptococcus pneumoniae, streptococcus pyogenes (group A) and other Streptococcus species; Hemophilus influenzae and parainfluenzae; Moraxella catarrhalis; anaerobic including Bacteroides fragilis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Hemophilus ducreyi, Neisseria gonorrheae and Chlamydia trachomatis. Azithromycin is also demonstrated activity in vitro against Legionella pneumophila, Mycoplasma pneumoniae and hominis; Campylobacter spp., Toxoplasma gondii and treponema pallidum.

Indication

Azithromycin is indicated for infections caused by susceptible organisms, in lower respiratory tract infections including bronchitis and pneumonia, skin and soft tissue infections, otitis media and in upper respiratory tract infections including sinusitis, pharyngitis and tonsillitis.

Azithromycin is indicated in the treatment of uncomplicated genital infections due to Chlamydia trachomatis.